Isoguvacine (hydrochloride)

Isoguvacine is a GABAA receptor agonist. It binds to rat synaptic cortical membranes (Ki = 55 nM) and activates alpha1beta2gamma2S, alpha2beta2gamma2S, alpha3beta2gamma2S, alpha5beta2gamma2S, and rho1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively). It inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM) and high potassium/low magnesium-induced seizures in rat pups. Chronic administration of isoguvacine (2 mg/kg) improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).Formal Name: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid, monohydrochloride. CAS Number: 68547-97-7. Molecular Formula: C6H9NO2 . HCl. Formula Weight: 163.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C1=CCNCC1)O.Cl. InChi Code: InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5,/h1,7H,2-4H2,(H,8,9),1H. InChi Key: SUWREQRNTXCCBL-UHFFFAOYSA-N.