inS3-54-A18

inS3-54-A18 is an inhibitor of STAT3. It selectively inhibits the binding of STAT3 to DNA over STAT1 at 25 µM. inS3-54-A18 (20 µM) inhibits STAT3 activity in a reporter assay using MDA-MB-231 breast cancer cells. It induces apoptosis in, and reduces migration and invasion of, A549 non-small cell lung cancer (NSCLC) and MDA-MB-231 cells when used at concentrations of 5 or 10 µM. inS3-54-A18 (200 mg/kg) reduces tumor volume in an A549 mouse xenograft model.Formal Name: 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-2H-pyrrol-2-one. CAS Number: 328998-53-4. Molecular Formula: C23H16ClNO2. Formula Weight: 373.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: ClC(C=C1)=CC=C1C=C2C=C(C3=CC=CC=C3)N(C4=CC=C(O)C=C4)C2=O. InChi Code: InChI=1S/C23H16ClNO2/c24-19-8-6-16(7-9-19)14-18-15-22(17-4-2-1-3-5-17)25(23(18)27)20-10-12-21(26)13-11-20/h1-15,26H. InChi Key: IMHWQIPPIXOVRK-UHFFFAOYSA-N.