Imperatorin

Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. It inhibits cyclin D1 expression and stops the cell cycle at G1. Studies suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.