Imperatorin

Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities, including anticancer, anti-inflammatory, and antioxidant properties. It decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in doxorubicin-resistant HepG2 (R-HepG2) cells, an effect that can be reversed by overexpression of MCL-1. Imperatorin inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells in vitro (IC50s = 28.1 and 43.3 µM, respectively) and reduces tumor growth in an R-HepG2 mouse xenograft model when administered at a dose of 50 mg/kg. Imperatorin inhibits LPS-induced increases in p38 MAPK, JNK, and IkappaBalpha phosphorylation, TNF-alpha, IL-6, and IL-1beta protein levels, and nuclear localization of NF-kappaB p65 in RAW 264.7 macrophages. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and ABTS radicals (EC50s = 19.48 and 10.93 µM, respectively). Imperatorin also has antibacterial, antiviral, and anticonvulsant activities.Formal Name: 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 482-44-0. Synonyms: Marmelosin, NSC 402949. Molecular Formula: C16H14O4. Formula Weight: 270.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 219, 249, 302 nm. SMILES: O=C1C=CC2=C(C(OC/C=C(C)/C)=C(OC=C3)C3=C2)O1. InChi Code: InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3. InChi Key: OLOOJGVNMBJLLR-UHFFFAOYSA-N.