Imiquimod-d9

Imiquimod-d9
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay26424-500 500 µg -

6 - 10 Werktage*

324,00 €
Cay26424-1 1 mg -

6 - 10 Werktage*

615,00 €
 
Imiquimod-d9 is intended for use as an internal standard for the quantification of imiquimod... mehr
Produktinformationen "Imiquimod-d9"
Imiquimod-d9 is intended for use as an internal standard for the quantification of imiquimod (Cay-14956) by GC- or LC-MS. Imiquimod is an imidazoquinoline agonist of toll-like receptor 7 (TLR7, EC50 = 2.12 µM). It increases TNF-alpha and IL-12 p40 production in IFN-gamma-treated murine peritoneal macrophages in a concentration- and MyD88-dependent manner. Topical application of imiquimod (30 µl of 5% cream) increases TNF and IFN levels at the application site in hairless mice. Imiquimod dose-dependently increases serum levels of IFN-alpha in mice when administered by gavage. It reduces tumor growth in an MC-26 model of murine colon cancer when administered at a dose of 30 mg/kg every three days. Imiquimod (5 mg/kg, intravaginally, twice daily) reduces vaginal viral titer and lesion formation in a guinea pig model of genital HSV-2 infection. Formulations containing imiquimod have been used in the treatment of actinic keratosis, superficial basal cell carcinoma, and external genital warts.Formal Name: 1-(2-(methyl-d3)propyl-1,1,2,3,3,3-d6)-1H-imidazo[4,5-c]quinolin-4-amine. CAS Number: 2712126-48-0. Molecular Formula: C14H7D9N4. Formula Weight: 249.4. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. SMILES: NC1=NC2=C(C3=C1N=CN3C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C=CC=C2. InChi Code: InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)/i1D3,2D3,7D2,9D. InChi Key: DOUYETYNHWVLEO-UEZIPFSLSA-N.
Schlagworte: 1-(2-(methyl-d3)propyl-1,1,2,3,3,3-d6)-1H-imidazo[4,5-c]quinolin-4-amine
Hersteller: Cayman Chemical
Hersteller-Nr: 26424

Eigenschaften

Anwendung: GC-MS, LC-MS, quantification, internal standard, TLR7 activator
MW: 249.4 D
Formel: C14H7D9N4
Reinheit: >99% deuterated forms (d1-d9)
Format: Solid

Datenbank Information

CAS : 2712126-48-0| Passende Produkte
KEGG ID : K05404 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302, H312, H315, H319, H332, H335
P-Sätze: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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