Imidaprilat

Imidaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 2.6 nM) and an active metabolite of the prodrug imidapril (Cay-18854). It inhibits bradykinin-induced contractions in isolated guinea pig ileum (IC50 = 1.7 nM). Imidaprilat (50 nM) reduces adhesion induced by chemokine (C-C-) motif ligand 2 (CCL2) of THP-1 monocytes to TNF-alpha-activated human umbilical vein endothelial cells (HUVECs). In vivo, imidaprilat (1 mg/kg) inhibits the angiotensin I-induced pressor response in unanesthetized normotensive rats.Formal Name: 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4S-imidazolidinecarboxylic acid. CAS Number: 89371-44-8. Synonyms: 6366A. Molecular Formula: C18H23N3O6. Formula Weight: 377.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1N(C([C@H](C)N[C@@H](CCC2=CC=CC=C2)C(O)=O)=O)[C@H](C(O)=O)CN1C. InChi Code: InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1. InChi Key: VFAVNRVDTAPBNR-UBHSHLNASA-N.