Imidapril (hydrochloride)

Imidapril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor imidaprilat. Imidapril is converted to imidaprilat by carboxylesterase 1 (CES1). It inhibits swine renal cortex ACE activity in vitro (IC50 = 9.9 µM) and the angiotensin I-induced pressor response in normotensive rats. Imidapril (2 mg/kg) decreases blood pressure in spontaneously hypertensive and two kidney-one clip (2K-1C) renal hypertensive rats. It decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet. Imidapril (5 mg/kg) reduces urinary albumin excretion, a marker of renal damage, in a mouse model of diabetes induced by streptozotocin (Cay-13104).Formal Name: 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4S-imidazolidinecarboxylic acid, monohydrochloride. CAS Number: 89396-94-1. Synonyms: TA-6366. Molecular Formula: C20H27N3O6 . HCl. Formula Weight: 441.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 210 nm. SMILES: O=C(OCC)[C@@H](N[C@@H](C)C(N1C(N(C)C[C@H]1C(O)=O)=O)=O)CCC2=CC=CC=C2.Cl. InChi Code: InChI=1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28,/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26),1H/t13-,15-,16-,/m0./s1. InChi Key: LSLQGMMMRMDXHN-GEUPQXMHSA-N.