IMD 0354

IMD 0354 is an IKKbeta (IKK2) inhibitor that blocks NF-kappaB phosphorylation (IC50 = ~250 nM) and subsequent NF-kappaB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1beta and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 µM by directly targeting the NF-kappaB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide. CAS Number: 978-62-1. Synonyms: IKK2 Inhibitor V. Molecular Formula: C15H8ClF6NO2. Formula Weight: 383.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 212, 266, 319 nm. SMILES: O=C(C1=C(O)C=CC(Cl)=C1)NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2. InChi Code: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25). InChi Key: CHILCFMQWMQVAL-UHFFFAOYSA-N.