Ilicicolin F

Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo (IC50s = 0.43 and 0.37 µM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd (IC50 = 85 µM). Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs = 1.66-3.33 and 6.66-13.33 µg/ml, respectively). It is cytotoxic to HeLa cells with an EC50 value of 0.003 µg/ml.Formal Name: 3-[(2E,4E)-5-[(1S,2S,3S,6R)-3-(acetyloxy)-1,2,6-trimethyl-5-oxocyclohexyl]-3-methyl-2,4-pentadien-1-yl]-5-chloro-2,4-dihydroxy-6-methyl-benzaldehyde. CAS Number: 22738-98-3. Synonyms: LL-Z 1272zeta. Molecular Formula: C25H31ClO6. Formula Weight: 463.0. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1[C@H](C)[C@](/C=C/C(C)=C/CC2=C(O)C(C=O)=C(C)C(Cl)=C2O)(C)[C@H](C)[C@@H](OC(C)=O)C1. InChi Code: InChI=1S/C25H31ClO6/c1-13(7-8-18-23(30)19(12-27)14(2)22(26)24(18)31)9-10-25(6)15(3)20(29)11-21(16(25)4)32-17(5)28/h7,9-10,12,15-16,21,30-31H,8,11H2,1-6H3/b10-9+,13-7+/t15-,16+,21-,25+/m0/s1. InChi Key: ACSLMZYXJATICN-IRMIYARYSA-N. Origin: Fungus/Unidentified sp..