IKK2-IN-4

Description: IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-alpha in PBMC induced by LPS. Target: IkappaB/IKK, TNF. Smiles: N(C(N)=O)C=1SC(=CC1C(N)=O)C2=CC=CC=C2. References: Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7,14(11):2817-22.