Ifenprodil (hemitartrate)

Ifenprodil is an antagonist of NR1A/NR2B subunit-containing NMDA receptors (IC50 = 340 nM). It is selective for NR1A/NR2B subunit-containing NMDA receptors over those containing NR1A/NR2A or NR1A/NR2C subunits (IC50s = 20 and >100 µM, respectively) but also binds to sigma 1 (sigma1) receptors, emopamil binding protein, and fungal C-8 sterol isomerase/ERG2 (Kis = 2, 5, and 1 nM, respectively), as well as alpha1 adrenergic receptors (alpha1-AR, IC50 = 110 nM), and the serotonin receptor types 5-HT1A and 5-HT2 (IC50s = 238 and 610 nM, respectively). Ifenprodil inhibits infection of MDCK cells by H1N1 and H3N2 influenza isolates in vitro (EC50s = 6.6 and 16.9 µM, respectively). It increases the production of NGF, BDNF, and GDNF in primary mouse astrocytes when used at a concentration of 150 µM. Ifenprodil also reduces maximal electroshock seizures in mice (ED50s = 16 and 7 mg/kg, respectively).Formal Name: alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethanol, 2R,3R-dihydroxybutanedioate (2:1). CAS Number: 23210-58-4. Synonyms: NP-120. Molecular Formula: C21H27NO2 . 1/2C4H6O6. Formula Weight: 400.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 227, 278 nm. SMILES: CC(C(C1=CC=C(O)C=C1)O)N(CC2)CCC2CC3=CC=CC=C3.OC([C@@H]([C@@H](O)C(O)=O)O)=O. InChi Code: InChI=1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17,5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3,1-2,5-6H,(H,7,8)(H,9,10)/t,,1-,2-/m..1/s1. InChi Key: DMPRDSPPYMZQBT-CEAXSRTFSA-N.