Ibutamoren (mesylate)

Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHSR). Ibutamoren is an orally-active, non-peptidic agonist of GHSR (Kd = 0.4 nM) and, as a result, is a GH secretagogue. It elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of aldosterone, luteinizing hormone, thyroxine, or prolactin.Formal Name: 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-propanamide, methanesulfonate. CAS Number: 159752-10-0. Synonyms: L-163,191, MK-0677. Molecular Formula: C27H36N4O5S . CH3SO3H. Formula Weight: 624.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 232, 280 nm. SMILES: O=C(N1CCC2(C(C=CC=C3)=C3N(S(C)(=O)=O)C2)CC1)[C@H](NC(C(C)(N)C)=O)COCC4=CC=CC=C4.OS(=O)(C)=O. InChi Code: InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27,1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33),1H3,(H,2,3,4)/t22-,/m1./s1. InChi Key: DUGMCDWNXXFHDE-VZYDHVRKSA-N.