Hypoxanthine-d4

Hypoxanthine-d4 is intended for use as an internal standard for the quantification of hypoxanthine (Cay-22254) by GC- or LC-MS. Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain. Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice. Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysunction, self-mutilation, and hyperuricemia.Formal Name: 1,9-dihydro-1,9-d2-6H-purin-6-one-2,8-d2. CAS Number: 2483831-32-7. Synonyms: 6-Hydroxypurine-d4. Molecular Formula: C5D4N4O. Formula Weight: 140.1. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C1C2=C(N=C([2H])N2[2H])N([2H])C([2H])=N1. InChi Code: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)/i1D,2D/hD2. InChi Key: FDGQSTZJBFJUBT-OPTZXGQFSA-N.