Hydroxyzine-d8 (hydrochloride)

Hydroxyzine-d8 is intended for use as an internal standard for the quantification of hydroxyzine (Cay-24039) by GC- or LC-MS. Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM). It binds competitively with the H1 receptor inverse agonist mepyramine (Cay-20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes. In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Cay-19686). In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules. Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test. Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.Formal Name: 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl-d8]ethoxy]-ethanol, dihydrochloride. CAS Number: 1808202-93-8. Molecular Formula: C21H19ClD8N2O2 . 2HCl. Formula Weight: 455.9. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Water: slightly soluble. SMILES: ClC1=CC=C(C(C2=CC=CC=C2)N3C([2H])([2H])C([2H])([2H])N(CCOCCO)C([2H])([2H])C3([2H])[2H])C=C1.Cl.Cl. InChi Code: InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25,,/h1-9,21,25H,10-17H2,2*1H/i10D2,11D2,12D2,13D2,,. InChi Key: ANOMHKZSQFYSBR-FLZNRFFQSA-N.