Hydralazine-d4 (hydrochloride)

Hydralazine-d4 is intended for use as an internal standard for the quantification of hydralazine (Cay-23121) by GC- or LC-MS. Hydralazine is an orally bioavailable vasodilator and antihypertensive agent. It decreases DNA methylation in Jurkat cells at a concentration of 10 µM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) at a concentration of 100 µM. Hydralazine (100 µM) also decreases nitric oxide production and expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS (Cay-19660, Cay-19661) and interferon-gamma (IFN-gamma). It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (Cay-16673, IC50s = 2.2 and 3.06 mM, respectively). Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats. Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.Formal Name: 1-hydrazinyl-phthalazine-5,6,7,8-d4, monohydrochloride. CAS Number: 2749234-32-8. Synonyms: 1-Hydrazinophthalazine-d4. Molecular Formula: C8H4D4N4 . HCl. Formula Weight: 200.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol:Water (1:1): soluble. SMILES: NN=C1NN=CC2=C1C([2H])=C([2H])C([2H])=C2[2H].Cl. InChi Code: InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8,/h1-5H,9H2,(H,11,12),1H/i1D,2D,3D,4D,. InChi Key: ZUXNZUWOTSUBMN-FOMJDCLLSA-N.