HUP-55

HUP-55 is an inhibitor of prolyl endopeptidase (IC50 = 5 nM). It reduces alpha-synuclein dimerization in Neuro2a cells, induces autophagy in HEK293 cells, and decreases hydrogen peroxide-induced increases in reactive oxygen species (ROS) production in SH-SY5Y cells when used at a concentration of 10 µM. HUP-55 (10 mg/kg) decreases ipsilateral paw use and striatal oligomeric alpha-synuclein levels in a mouse model of Parkinson's disease induced by adenoviral delivery of an alpha-synuclein-encoding vector (AAV-alphaSyn).Formal Name: (S)-1-(4-methyl-2-(3-phenylpropyl)oxazol-5-yl)pyrrolidine-2-carbonitrile. Molecular Formula: C18H21N3O. Formula Weight: 295.4. Purity: >98%. Formulation: (Request formulation change), A solution in acetonitrile. Solubility: Acetonitrile: 10 mg/ml. SMILES: CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1. InChi Code: InChI=1S/C18H21N3O/c1-14-18(21-12-6-10-16(21)13-19)22-17(20-14)11-5-9-15-7-3-2-4-8-15/h2-4,7-8,16H,5-6,9-12H2,1H3/t16-/m0/s1. InChi Key: FEEUIAMWBWZZNX-INIZCTEOSA-N.