HM43239

HM43239 is an inhibitor of wild-type (WT) and internal tandem duplication (ITD) mutant FMS-related tyrosine kinase 3 (FLT3, IC50s = 1.1 and 1.8 nM, respectively). It also inhibits VEGFR2 and spleen tyrosine kinase (Syk) by 100 and 95%, respectively, when used at a concentration of 100 nM. HM43239 inhibits the growth of MOLM-13 and MV4-11 leukemia cells (GI50s = 5.2 and 1.3 nM, respectively).Formal Name: rel-5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-2-pyrimidinamine. CAS Number: 2294874-49-8. Synonyms: Tuspetinib. Molecular Formula: C29H33ClN6. Formula Weight: 501.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 215, 283, 330 nm. SMILES: ClC1=CN=C(NC2=CC(C3CC3)=CC(CN4C[C@H](N[C@H](C4)C)C)=C2)N=C1C5=CNC6=CC(C)=CC=C56. InChi Code: InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+. InChi Key: FZLSDZZNPXXBBB-KDURUIRLSA-N.