Hexamethonium (bromide)

Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs). It decreases acetylcholine release induced by carbamoylcholine (Cay-14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml. It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg. Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats. Formulations containing hexamethonium were previously used in the treatment of hypertension.Formal Name: N1,N1,N1,N6,N6,N6-hexamethyl-1,6-hexanediaminium, dibromide. CAS Number: 55-97-0. Molecular Formula: C12H30N2 . 2Br. Formula Weight: 362.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 16 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]. InChi Code: InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6,,/h7-12H2,1-6H3,2*1H/q+2,,/p-2. InChi Key: FAPSXSAPXXJTOU-UHFFFAOYSA-L.