Hederacoside C

Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity. It is an inhibitor of acetylcholinesterase (AChE, IC50 = 31.3 µM). Hederacoside C (0.5-5 µg) inhibits mutagenicity induced by aflatoxin B1 (Cay-11293) in S. typhimurium agar cultures from 21 to 67%. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity in isolated mouse peritoneal macrophages stimulated by LPS when used at concentrations ranging from 5 to 10 µM. Hederacoside C (0.02 mg/kg) reduces carrageenan-induced hind paw edema by 37% compared to vehicle control in a rat model of acute inflammation. It reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, when administered at a dose of 40 mg/kg. Hederacoside C (5 mg/kg, i.p.) reduces serum levels of TNF-alpha and IL-1beta in LPS-challenged mice by 60 and 65%, respectively.Formal Name: 3beta-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid, O-6-deoxy-alpha-L-mannopyranosyl-(1->4alpha)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester. CAS Number: 14216-03-6. Synonyms: Hederasaponin C, Kalopanaxsaponin B. Molecular Formula: C59H96O26. Formula Weight: 1221.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml. SMILES: CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])[C@@](CO)(C)[C@@H](O[C@]9([H])OC[C@H](O)[C@H](O)[C@H]9O[C@@]%10([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10)CC[C@]8(C)[C@@]7([H])CC=C6[C@]2([H])C1. InChi Code: InChI=1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27-,28-,29+,30+,31+,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1. InChi Key: RYHDIBJJJRNDSX-MCGLQMIESA-N.