Heclin

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 µM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively). It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 µM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 µM).Formal Name: N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide. CAS Number: 890605-54-6. Molecular Formula: C17H17NO3. Formula Weight: 283.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/mL, Ethanol: 10 mg/mL. lambdamax: 224, 342 nm. SMILES: CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O. InChi Code: InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+. InChi Key: SPTWXRJNCFIDRQ-ZHACJKMWSA-N.