Haloperidol-d4

Haloperidol-d4 is intended for use as an internal standard for the quantification of haloperidol (Cay-12014) by GC- or LC-MS. Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic and histamine H1 receptors, as well as the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively). It inhibits stereotypic behavior induced by apomorphine (Cay-16094) and amphetamine in rats (ID50s = 0.532 and 0.101 µmol/kg, respectively). Haloperidol also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner. Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome.Formal Name: 4-(4-(4-chlorophenyl-2,3,5,6-d4)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one. CAS Number: 1189986-59-1. Molecular Formula: C21H19ClD4FNO2. Formula Weight: 379.9. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: OC1(CCN(CCCC(C2=CC=C(F)C=C2)=O)CC1)C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H]. InChi Code: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2/i5D,6D,7D,8D. InChi Key: LNEPOXFFQSENCJ-KDWZCNHSSA-N.