Haloperidol

Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic and histamine H1 receptors, as well as the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively). It inhibits stereotypic behavior induced by apomorphine (Cay-16094) and amphetamine in rats (ID50s = 0.532 and 0.101 µmol/kg, respectively). Haloperidol also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner. Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome.Formal Name: 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone. CAS Number: 52-86-8. Synonyms: McN-JR 1625, NSC 170973, NSC 615296, R 1625. Molecular Formula: C21H23ClFNO2. Formula Weight: 375.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 203, 221, 242 nm. SMILES: OC1(CCN(CCCC(C2=CC=C(F)C=C2)=O)CC1)C3=CC=C(Cl)C=C3. InChi Code: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2. InChi Key: LNEPOXFFQSENCJ-UHFFFAOYSA-N.