HA-100 (hydrochloride)

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 µM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC50 = 240 µM).Formal Name: 5-(1-piperazinylsulfonyl)-isoquinoline, dihydrochloride. CAS Number: 210297-47-5. Synonyms: C-1. Molecular Formula: C13H15N3O2S . 2HCl. Formula Weight: 350.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1.1 mg/ml. lambdamax: 216, 275, 323 nm. SMILES: O=S(C1=C2C(C=NC=C2)=CC=C1)(N3CCNCC3)=O.Cl.Cl. InChi Code: InChI=1S/C13H15N3O2S.2ClH/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13,,/h1-5,10,14H,6-9H2,2*1H. InChi Key: ZKQAPKKKTQCVKG-UHFFFAOYSA-N.