GX-674

GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7). It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively). GX-674 is also selective for Nav1.7 over Nav1.1, Nav1.3-1.5, and Nav1.8 but does inhibit Nav1.2 and, to a lesser extent, Nav1.6.Formal Name: 4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide. CAS Number: 1432913-36-4. Molecular Formula: C21H13ClF2N6O3S2. Formula Weight: 534.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): Slightly soluble. SMILES: O=S(NC1=NC=NS1)(C2=C(F)C=C(OC3=C(C4=CC5=C(C=C4)N=C(N)N5)C=C(Cl)C=C3)C(F)=C2)=O. InChi Code: InChI=1S/C21H13ClF2N6O3S2/c22-11-2-4-17(12(6-11)10-1-3-15-16(5-10)29-20(25)28-15)33-18-7-14(24)19(8-13(18)23)35(31,32)30-21-26-9-27-34-21/h1-9H,(H3,25,28,29)(H,26,27,30). InChi Key: NLTQZTZBFNPMDH-UHFFFAOYSA-N.