GW 3965 (hydrochloride)

The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM, respectively. It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism. GW 3965 also affects inflammation and pressor responses through LXRalpha and LXRbeta.Formal Name: 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride. CAS Number: 405911-17-3. Molecular Formula: C33H31ClF3NO3 . HCl. Formula Weight: 618.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 2 mg/ml. lambdamax: 204, 272 nm. SMILES: OC(CC1=CC(OCCCN(CC2=C(Cl)C(C(F)(F)F)=CC=C2)CC(C3=CC=CC=C3)C4=CC=CC=C4)=CC=C1)=O.Cl. InChi Code: InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26,/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40),1H. InChi Key: NMPUWJFHNOUNQU-UHFFFAOYSA-N.