Gusacitinib

Gusacitinib is a dual inhibitor of JAKs (IC50s = 46, 4, and 11 nM for JAK1-3, respectively) and Syk family kinases (IC50s = 5 and 8 nM for SyK and TYK2, respectively).Formal Name: 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile. CAS Number: 1425381-60-7. Synonyms: ASN-002. Molecular Formula: C24H28N8O2. Formula Weight: 460.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 267 nm. SMILES: N#CCC1CCN(CC1)C2=NC(C=NN3)=C(C(NC4=CC=C(N5CCC(CC5)O)C=C4)=N2)C3=O. InChi Code: InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29). InChi Key: NLFLXLJXEIUQDL-UHFFFAOYSA-N.