Guanosine 5'-triphosphate trisodium salt

Description: Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) activates signal-transducing G proteins involved in cellular processes such as proliferation, differentiation, and activation of intracellular kinase cascades. It regulates proliferation and apoptosis through the hydrolysis by small GTPases Ras and Rho, and plays a role in vesicle docking, fusion, and formation via Rab. Additionally, GTP serves as an energy-rich precursor for the biosynthesis of DNA and RNA. Target: Endogenous Metabolite. Smiles: O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([O-])=O)([O-])=O)(O)=O)N2C3=C(C(N=C(N3)N)=O)N=C2.[Na+].[Na+].[Na+]. References: Gutkind, Silvio J . Cell growth control by G protein-coupled receptors: from signal transduction to signal integration[J]. Oncogene, 1998, 17(11):1331-1342.