Guanfu base A

Description: Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 µM in HLMs, Ki: 0.37 µM for rCYP2D6). It also inhibits HERG channel current. Target: HER, Potassium Channel, P450. Smiles: [H][C@@]12CC34CC(=C)[C@]5([H])[C@@H](O)[C@@]3([H])[C@@]36C[C@H](C[C@@](C)(CN1C3[C@@]4(O)[C@@H]5OC(C)=O)[C@@]26[H])OC(C)=O. References: Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May,43(5):713-24.