Guaifenesin

Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin (50 mg/kg, p.o.) increases phenol red secretion, a marker of expectorant activity, in rats. Formulations containing guaifenesin have been used as expectorants in the treatment of the common cold and chronic bronchitis.Formal Name: 3-(2-methoxyphenoxy)-1,2-propanediol. CAS Number: 93-14-1. Synonyms: MY-301, NSC 62112, SL 90, XL90. Molecular Formula: C10H14O4. Formula Weight: 198.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 226, 274 nm. SMILES: COC1=C(OCC(O)CO)C=CC=C1. InChi Code: InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3. InChi Key: HSRJKNPTNIJEKV-UHFFFAOYSA-N.