GTP 14564

GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRbeta). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.Formal Name: 3-phenyl-1H-benzofuro[3,2-c]pyrazole. CAS Number: 34823-86-4. Molecular Formula: C15H10N2O. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 1 mg/ml. lambdamax: 248, 272, 304 nm. SMILES: C12=CC=CC=C1OC3=C2NN=C3C4=CC=CC=C4. InChi Code: InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17). InChi Key: DZQLVVLATXPWBK-UHFFFAOYSA-N.