GSK2850163

GSK2850163 is an inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha, IC50s = 0.2 and 0.02 µM for RNase and kinase activity, respectively). It is selective for IRE1alpha over Ron and FGFR1 (IC50s = 4.4 and 17 µM), as well as a panel of 282 kinases at 10 µM. GSK2850163 (8 µM) inhibits endoplasmic reticulum (ER) stress-induced increases in the splicing of mRNA encoding X-box binding protein 1 (XBP1) in eight multiple myeloma cell lines. It reduces viral replication in tick-borne encephalitis virus-infected SH-SY5Y and SNB-19 cells when used at a concentration of 0.5 µM or tick-borne encephalitis virus-infected Caco-2 cells at 1 µM.Formal Name: 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5R]decane-7-carboxamide. CAS Number: 2121989-91-9. Synonyms: GSK163. Molecular Formula: C24H29Cl2N3O. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: O=C(N1CCC[C@@]2(CN(CC3=CC(Cl)=C(Cl)C=C3)CC2)C1)NCC4=CC=C(C)C=C4. InChi Code: InChI=1S/C24H29Cl2N3O/c1-18-3-5-19(6-4-18)14-27-23(30)29-11-2-9-24(17-29)10-12-28(16-24)15-20-7-8-21(25)22(26)13-20/h3-8,13H,2,9-12,14-17H2,1H3,(H,27,30)/t24-/m1/s1. InChi Key: YFDASBFQKMHSSJ-XMMPIXPASA-N.