GSK1016790A

Description: GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells. Target: TRP/TRPV Channel, Calcium Channel. Smiles: CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)N1CCN(CC1)C(=O)[C@H](CO)NS(=O)(=O)c1ccc(Cl)cc1Cl. References: Thorneloe KS, et al. J Pharmacol Exp Ther. 2008, 326(2):432-42.