GSK 417651A

GSK 417651A is an inhibitor of transient receptor potential canonical 3 (TRPC3) and TRPC6 (IC50 = ~0.4 µM for both). It inhibits migration of isolated human fibroblastic valve interstitial cells into the wounded area in a scratch test assay when used at a concentration of 2 µM.Formal Name: (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-methanone. CAS Number: 736945-96-3. Molecular Formula: C20H19N3O2S. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 271 nm. SMILES: O=C(C1=CSC(NC2=CC=C(OC)C=C2)=N1)N(C3)CCC4=C3C=CC=C4. InChi Code: InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22). InChi Key: NTXBDULODNTCKP-UHFFFAOYSA-N.