GS143

Description: GS143 is a selective IkappaBalpha ubiquitination inhibitor with an IC50 of 5.2 µM for SCFbetaTrCP1-mediated IkappaBalpha ubiquitylation. It suppresses NF-kappaB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties. Target: NF-kappaB, IkappaB/IKK, E1/E2/E3 Enzyme. Smiles: OC(=O)c1ccc(cc1)N1N=C(Cc2ccccc2)\C(=C/c2ccc(o2)-c2ccccc2F)C1=O. References: Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep,123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.