GMX1777

GMX1777 is a prodrug form of the nicotinamide phosphoribosyltransferase (Nampt) inhibitor CHS-828 (Cay-11021). Intravenous administration of GMX1777 (75 and 150 mg/kg) reduces NAD+ levels in tumors, but not muscle tissue, in a DMS 273 lung cancer mouse xenograft model. GMX1777 (50 mg/kg per day), in combination with radiation, decreases tumor diameter and microvessel density in C666-1 nasopharyngeal and FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft models.Formal Name: 4-[[[[6-(4-chlorophenoxy)hexyl]imino](cyanoamino)methyl]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-pyridinium, monochloride. CAS Number: 432037-57-5. Synonyms: EB1627, Teglarinad. Molecular Formula: C30H43ClN5O8 . Cl. Formula Weight: 672.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: N#CNC(NCCCCCCOC1=CC=C(C=C1)Cl)=NC2=CC=[N+](COC(OCCOCCOCCOCCOC)=O)C=C2.[Cl-]. InChi Code: InChI=1S/C30H42ClN5O8.ClH/c1-38-16-17-39-18-19-40-20-21-41-22-23-43-30(37)44-25-36-13-10-27(11-14-36)35-29(34-24-32)33-12-4-2-3-5-15-42-28-8-6-26(31)7-9-28,/h6-11,13-14H,2-5,12,15-23,25H2,1H3,(H,33,34),1H. InChi Key: DAHMXVAETAAQOZ-UHFFFAOYSA-N.