GMQ (hydrochloride)

GMQ is an activator of acid-sensing ion channel 3 (ASIC3). It evokes rapid inward currents with little desensitization in CHO cells expressing ASIC3 (EC50 = 67 µM at neutral pH). It is also an inhibitor of the GABAA receptor (IC50 = 0.39 µM in primary rat hippocampal neurons). GMQ has stimulatory effects on large-conductance calcium-activated potassium (KCa1.1/BKCa) channels in GH3 rat pituitary cells and on non-selective cation currents in Rolf B1.T olfactory sensory neurons. It increases paw licking time in Asic3+/+ and, to a lesser extent, Asic3-/- mice when administered at a dose of 100 µM, an effect that can be blocked by the ASIC inhibitor amiloride (Cay-14409).Formal Name: N-(4-methyl-2-quinazolinyl)-guanidine, monohydrochloride. CAS Number: 5361-15-9. Molecular Formula: C10H11N5 . HCl. Formula Weight: 237.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 246 nm. SMILES: CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl. InChi Code: InChI=1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12,/h2-5H,1H3,(H4,11,12,13,14,15),1H. InChi Key: VNPZWQRWOHFAPD-UHFFFAOYSA-N.