Glyburide

White to off-white solid. Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol (gentle warming). Antidiabetic compound, Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1), Causes cell membrane depolarization and opening of voltage-dependent calcium channel, Increases intracellular calcium and stimulates insulin secretion in beta cells, NLRP3 inflammasome inhibitor, Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor, Shown to have anti-leishmanial activity, Potential inhibitor of collagenases.