GLP-1R Agonist DMB

GLP-1R agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R, KB = 26.3 nM for the recombinant human receptor). It inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor with an EC50 value of 101 nM. GLP-1R (100 and 1,000 nM) increases insulin levels induced by D-(+)-glucose (Cay-23733) in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice. It reduces fasting plasma glucose levels in mice when administered at a dose of 5 µmol/kg.Formal Name: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine. CAS Number: 281209-71-0. Molecular Formula: C13H15Cl2N3O2S. Formula Weight: 348.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 223, 264 nm. SMILES: ClC1=C(Cl)C=C(N=C(NC(C)(C)C)C(S(C)(=O)=O)=N2)C2=C1. InChi Code: InChI=1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18). InChi Key: GNZCSGYHILBXLL-UHFFFAOYSA-N.