Glimepiride

Glimepiride is an inhibitor of sulfonylurea receptors (SURs) linked to the inwardly rectifying potassium channel (Kir6.2, IC50s = 3, 5.4, and 7.3 nM for SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2, respectively, in Xenopus oocytes expressing the mouse receptor). It also induces intracellular insulin receptor (InsR) complex dissociation and insulin degradation in HepG2 cells when used at a concentration of 20 µM. Glimepiride (0.05 mg/kg per day) decreases blood glucose and plasma insulin levels in a KKAy mouse model of insulin-resistant type 2 diabetes. It reduces hemoglobin A1c (HbA1c) levels in the same model when administered at a dose of 0.5 mg/kg per day. Formulations containing glimepiride have been used in the treatment of type 2 diabetes mellitus.Formal Name: 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide. CAS Number: 93479-97-1. Synonyms: HOE 490. Molecular Formula: C24H34N4O5S. Formula Weight: 490.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 3 mg/ml. lambdamax: 228 nm. SMILES: O=S(C1=CC=C(CCNC(N2C(C(CC)=C(C)C2)=O)=O)C=C1)(NC(N[C@H]3CC[C@H](C)CC3)=O)=O. InChi Code: InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-. InChi Key: WIGIZIANZCJQQY-RUCARUNLSA-N.