Ginsenoside F1

Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities. It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo. GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice. It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO). GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer's disease.Formal Name: (3beta,6alpha,12beta)-3,6,12-trihydroxydammar-24-en-20-yl beta-D-glucopyranoside. CAS Number: 53963-43-2. Synonyms: GF1, Panaxoside A Progenin. Molecular Formula: C36H62O9. Formula Weight: 638.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml, Ethanol: 10 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O)[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]4([H])C1. InChi Code: InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,45-31-29(43)28(42)27(41)23(18-37)44-31)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(40)32(3,4)30(33)22(39)17-35(24,34)7/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31-,33+,34+,35+,36-/m0/s1. InChi Key: XNGXWSFSJIQMNC-FIYORUNESA-N. Origin: Plant/Panax ginseng.