Gemfibrozil

Gemfibrozil is a peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-kappaB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.Formal Name: 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid. CAS Number: 25812-30-0. Synonyms: CI-719. Molecular Formula: C15H22O3. Formula Weight: 250.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 16 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 219, 275, 281 nm. SMILES: CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1. InChi Code: InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17). InChi Key: HEMJJKBWTPKOJG-UHFFFAOYSA-N.