GDC-6036

GDC-6036 is a covalent inhibitor of K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C). It decreases tumor volume in a PaCa-2 pancreatic cancer mouse xenograft model when administered at doses ranging from 1 to 100 mg/kg per day.Formal Name: 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-2-propen-1-one. CAS Number: 2417987-45-0. Synonyms: Divarasib, RG-6330. Molecular Formula: C29H32ClF4N7O2. Formula Weight: 622.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: CN(CCC1)C1COC2=NC(N3C(C)CN(C(C=C)=O)CC3)=C(C=C(C(C4=C(C(F)(F)F)C(C)=CC(N)=N4)=C5F)Cl)C5=N2. InChi Code: InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36). InChi Key: ZRBPIAWWRPFDPY-UHFFFAOYSA-N.