Gardiquimod

Description: Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 µM, Gardiquimod specifically activates TLR7. Target: TLR, HIV Protease. Smiles: CCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O. References: Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun,29(6):907-18.