gamma-Linolenic acid

Description: gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown gamma-Linolenic Acid to have induced reactive oxygen species generation including lipid peroxidation, cell growth inhibition, and heme oxygenase-1 production for antioxidant protection against oxidative stress. Further experiments have noted that gamma-Linolenic acid inhibits inflammatory responses through inactivation of NFkappaB and activator protein-1 by suppressed oxidative stress. Target: Endogenous Metabolite. Smiles: CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O. References: Sinha R , Ahn J , Sampson J N , et al. Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations[J]. PLOS ONE, 2016, 11(3):e0152126.