(-)-Gallocatechin

(-)-Gallocatechin ((-)-GC) is an epimer of (-)-epigallocatechin ((-)-EGC, Cay-11809). They are flavan-3-ols and members of the catechin family of polyphenolic antioxidants found in green tea and other plant extracts. Both (-)-GC and (-)-EGC are potent antioxidants and significantly inhibit the proliferation of HCT116 and SW480 cancer cells. (-)-GC also inhibits the aggregation of amyloid beta peptide in vitro (IC50 = 17.5 µM). With increasing temperature, the steaming of green tea leaves results in the reduction of 2,3-cis isomers, like (-)-EGC, and an increase in 2,3-trans isomers, like (-)-GC.Formal Name: (2S,3R)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol. CAS Number: 3371-27-5. Synonyms: (-)-GC. Molecular Formula: C15H14O7. Formula Weight: 306.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 210, 269 nm. SMILES: OC1=CC([C@H]2[C@H](O)CC3=C(O)C=C(O)C=C3O2)=CC(O)=C1O. InChi Code: InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15+/m1/s1. InChi Key: XMOCLSLCDHWDHP-DOMZBBRYSA-N.