Fosphenytoin (sodium salt)

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse model of maximal electroshock seizures similar to that of phenytoin (ED50s = 16 and 8 mg/kg, respectively). It also has antiarrhythmic activity in isolated guinea pig atria and in anesthetized dogs. Formulations containing fosphenytoin have been used in the treatment of status epilepticus.Formal Name: 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt. CAS Number: 92134-98-0. Synonyms: ACC-9653, Cl-982. Molecular Formula: C16H13N2O6P . 2Na. Formula Weight: 406.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: >1mg/ml, Ethanol: >1mg/ml. SMILES: O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)N3)N(COP([O-])([O-])=O)C3=O.[Na+].[Na+]. InChi Code: InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23,,/h1-10H,11H2,(H,17,20)(H2,21,22,23),,/q,2*+1/p-2. InChi Key: GQPXYJNXTAFDLT-UHFFFAOYSA-L.