Fosinopril (sodium salt)

Fosinopril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure. Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.Formal Name: 4S-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, monosodium salt. CAS Number: 88889-14-9. Synonyms: SQ 28,555. Molecular Formula: C30H45NO7P . Na. Formula Weight: 585.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: 1 mg/ml. SMILES: O=C(N1[C@H](C([O-])=O)C[C@@H](C2CCCCC2)C1)CP(CCCCC3=CC=CC=C3)(O[C@H](OC(CC)=O)C(C)C)=O.[Na+]. InChi Code: InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24,/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35),/q,+1/p-1/t25-,26+,30+,39?,/m1./s1. InChi Key: TVTJZMHAIQQZTL-TXDYNIFHSA-M.