Fosifloxuridine nafalbenamide

Description: Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells. Target: DNA/RNA Synthesis. Smiles: O(P(OC[C@H]1O[C@H](C[C@@H]1O)N2C(=O)NC(=O)C(F)=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)C=4C5=C(C=CC4)C=CC=C5. References: Fiona G. McKissock, et al. Abstract 1848: NUC-3373 induces ER stress and the release of damage associated molecular patterns in colorectal cancer cells. Cancer Res August 15 2020 (80) (16 Supplement) 1848.