Formoterol (hemifumarate hydrate)

Formoterol is a selective agonist of the beta2-adrenergic receptor (beta2-AR, Kis = 7.58 and 2,630 nM for beta2- and beta1-ARs, respectively). It is selective for beta-ARs in isolated guinea pig trachea over those in atrial tissue (pD2s = 9.29 and 6.98, respectively) and has a long duration of action. Aerosolized formoterol (10 µg/ml, inhaled) prevents the late asthmatic response and eosinophil and macrophage infiltration in bronchoalveolar lavage fluid (BALF), and as well as reduces bronchial reactivity in a guinea pig model of allergic asthma induced by ovalbumin. Formulations containing formoterol have been used, alone and in combination with other compounds, in the treatment of chronic obstructive pulmonary disease and asthma.Formal Name: rel-N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide, 2E-butenedioate (2:1), hydrate. Molecular Formula: C19H24N2O4 . 1/2C4H4O4 [XH2O]. Formula Weight: 402.5. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 20 mg/ml, Methanol: 1 mg/ml, Water: Slightly Soluble. lambdamax: 215, 285 nm. SMILES: COC1=CC=C(C[C@H](C)NC[C@@H](O)C2=CC(NC([H])=O)=C(O)C=C2)C=C1.OC(/C=C/C(O)=O)=O.COC3=CC=C(C[C@H](C)NC[C@@H](O)C4=CC(NC([H])=O)=C(O)C=C4)C=C3.O. InChi Code: InChI=1S/2C19H24N2O4.C4H4O4.H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22,5-3(6)1-2-4(7)8,/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22),1-2H,(H,5,6)(H,7,8),1H2/b,,2-1+,/t2*13-,19+,,/m00../s1. InChi Key: BPXZSHHCUKRDHD-PGVRECGZSA-N.