FM-381

FM-381 is a potent inhibitor of JAK3 (IC50 = 127 pM). It is 400-, 2,700-, and 3,600-fold selective for JAK3 over JAK1, JAK2, and TYK3 and only inhibits 11 kinases by less than 50 percent in a panel of 410 kinases when used at a concentration of 500 nM. FM-381 (1 µM) blocks JAK3-dependent STAT5 phosphorylation but not JAK3-independent STAT3 signaling in IL-2- and IL-6-stimulated T cells, respectively.Formal Name: 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-2-propenamide. CAS Number: 2226521-65-7. Molecular Formula: C24H24N6O2. Formula Weight: 428.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml. lambdamax: 240, 370 nm. SMILES: O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=C(C(C=CN4)=C4N=C3)N2C5CCCCC5)O1. InChi Code: InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+. InChi Key: GJMZWYLOARVASY-NTCAYCPXSA-N.